Neuronal intracellular chloride ion concentrations and their regulatory mechanisms.
نویسندگان
چکیده
منابع مشابه
Regulatory Domains and Their Mechanisms.
The concept of gene regulation is being refined as our understanding of the role of enhancer elements grows. Although described more than 30 years ago, the mechanisms through which these cis-regulating elements operate remain under debate. With the recognition that most of the human genetic variation contributing to common disease risk lies outside of genes and probably in enhancers, unraveling...
متن کاملIntracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury.
Because hypoxic/ischemic neurodegeneration appears to be in part linked to glutamate neurotoxicity, we measured intracellular calcium (Ca2+i) levels in cultured hippocampal neurons during exposure to toxic doses of glutamate (GLU) and to an anoxic environment simulated by sodium cyanide (NaCN). Changes in Ca2+i produced by cyanide greatly exceeded those induced by GLU. The NaCN response was mim...
متن کاملClC-2 channels regulate neuronal excitability, not intracellular chloride levels.
Synaptic inhibition by GABA(A) receptors requires a transmembrane chloride gradient. Hyperpolarization or shunting results from outward current produced by chloride flowing down this gradient, into the cell. Chloride influx necessarily depletes the chloride gradient. Therefore, mechanisms that replenish the gradient (by reducing intracellular chloride concentration, [Cl(-)](i)) are crucial for ...
متن کاملA multi-ion permeation mechanism in neuronal background chloride channels
Unitary current/voltage relationships of background Cl channels of rat hippocampal neurons were determined for varied gradients and absolute concentrations of NaCl. The channels revealed permeabilities for both Cl and Na ions. A hyperlinear increase of unitary conductance, observed for a symmetrical increase of salt concentration from 300 and 600 mM, indicated a multi-ion permeation mechanism. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1992
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.99.307